Ethambutol

CAT: 0804-HY-B0535-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0535-01Size:5 mg
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Description
Ethambutol is an antimycobacterial compound that prevents cell wall formation by inhibiting arabinosyltransferase activity. Ethambutol can be used to establish animal models of hyperuricemia and optic neuropathy.
CAS Number
[74-55-5]
UNSPSC
12352211
Hazard Statement
H315, H319, H320
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ethambutol.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 200 mg/mL
Smiles
CC[C@H](NCCN[C@@H](CC)CO)CO
Molecular Formula
C10H24N2O2
Molecular Weight
204.31
Precautions
H315, H319, H320
References & Citations
[1]Ethambutol. Tuberculosis (Edinb), 2008. 88 (2) : p. 102-5.|[2]Rastogi N, et al. In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages. Curr Microbiol, 1996. 33 (3) : p. 167-75.|[3]Kaur D, et al. Khuller, In vitro, ex-vivo and in vivo activities of ethambutol and sparfloxacin alone and in combination against mycobacteria. Int J Antimicrob Agents, 2001. 17 (1) : p. 51-5.|[4]Kang L, et al. Total glucosides of herbaceous peony (Paeonia lactiflora Pall.) flower attenuate adenine- and ethambutol-induced hyperuricaemia in rats. J Ethnopharmacol. 2020 Oct 28;261:113054.|[5]Pham AQ, et al. Pyrazinamide-induced hyperuricemia. P T. 2014 Oct;39 (10) :695-715.|[6]Nusanti S, et al. The Effect of Citicoline on Ethambutol Optic Neuropathy: Histopathology and Immunohistochemistry Analysis of Retina Ganglion Cell Damage Level in Rat Model. J Ocul Pharmacol Ther. 2022 Oct;38 (8) :584-589.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Antimicrob Agents Chemother. 2025 Sep 11:e0079525.|Commun Biol. 2025 Oct 6;8 (1) :1425.|mLife. 2025 Apr 15;4 (2) :155-168.|ACS Chem Biol. 2022 Jan 21;17 (1) :39-53.

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