Ethambutol

• Description:

  Ethambutol is an antimycobacterial compound that prevents cell wall formation by inhibiting arabinosyltransferase activity. Ethambutol can be used to establish animal models of hyperuricemia and optic neuropathy.

• UNSPSC:

  12352211

• Hazard Statement:

  H315, H319, H320

• Target:

  Antibiotic; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/ethambutol.html

• Purity:

  98.0

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 200 mg/mL

• Smiles:

  CC[C@H](NCCN[C@@H](CC)CO)CO

• Molecular Formula:

  C10H24N2O2

• Molecular Weight:

  204.31

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]Ethambutol. Tuberculosis (Edinb), 2008. 88 (2) : p. 102-5.|[2]Rastogi N, et al. In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages. Curr Microbiol, 1996. 33 (3) : p. 167-75.|[3]Kaur D, et al. Khuller, In vitro, ex-vivo and in vivo activities of ethambutol and sparfloxacin alone and in combination against mycobacteria. Int J Antimicrob Agents, 2001. 17 (1) : p. 51-5.|[4]Kang L, et al. Total glucosides of herbaceous peony (Paeonia lactiflora Pall.) flower attenuate adenine- and ethambutol-induced hyperuricaemia in rats. J Ethnopharmacol. 2020 Oct 28;261:113054.|[5]Pham AQ, et al. Pyrazinamide-induced hyperuricemia. P T. 2014 Oct;39 (10) :695-715.|[6]Nusanti S, et al. The Effect of Citicoline on Ethambutol Optic Neuropathy: Histopathology and Immunohistochemistry Analysis of Retina Ganglion Cell Damage Level in Rat Model. J Ocul Pharmacol Ther. 2022 Oct;38 (8) :584-589.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Citation 01:

  Antimicrob Agents Chemother. 2025 Sep 11:e0079525.|Commun Biol. 2025 Oct 6;8 (1) :1425.|mLife. 2025 Apr 15;4 (2) :155-168.|ACS Chem Biol. 2022 Jan 21;17 (1) :39-53.

• CAS Number:

  [74-55-5]