Ingenol 3-monobenzoate

Ingenol 3-monobenzoate

• CAS Number: 83036-64-0
• UNSPSC Description: Ingenol 3-monobenzoate (Ingenol 3-benzoate) is a disgust inducing agent. Ingenol 3-monobenzoate can bind to and activate PKC (Ki=0.14 nM), inhibit the gene expression of phosphoenolpyruvate carboxykinase, thereby inhibiting gluconeogenesis, and increasing blood cortisol levels, producing food aversion[1].
• Target Antigen: PKC
• Type: Natural Products
• Related Pathways: Epigenetics;TGF-beta/Smad
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/ingenol-3-monobenzoate.html
• Smiles: O[C@@]12[C@]3(C=C([C@@H]2OC(C4=CC=CC=C4)=O)C)C([C@](C=C([C@H]1O)CO)([H])[C@@]5([H])[C@@](C5(C)C)([H])C[C@H]3C)=O
• Molecular Weight: 452.54
• References & Citations: [1]Kronberg, et al. "Potential aversive compounds in leafy spurge for ruminants and rats." Journal of chemical ecology 21 (1995): 1387-1399.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported