Ingenol

• Description :

  Ingenol is a PKC activator, with a Ki of 30 μM, with antitumor activity.

• Product Name Alternative :

  (-) -Ingenol

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  PKC

• Type :

  Natural Products

• Related Pathways :

  Epigenetics; TGF-beta/Smad

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Ingenol.html

• Purity :

  99.51

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O[C@@]([C@@H](C(CO)=C[C@@]1([H])[C@H](C2(C)C)[C@H]2C3)O)([C@H]4O)[C@]([C@@H]3C)(C=C4C)C1=O

• Molecular Formula :

  C20H28O5

• Molecular Weight :

  348.44

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Hasler CM, et al. Specific binding to protein kinase C by ingenol and its induction of biological responses. Cancer Res. 1992 Jan 1;52 (1) :202-8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• Isoform :

  PKC

• CAS Number :

  [30220-46-3]