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Y134

CAT: 0804-HY-103457-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103457-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Y134 is a selective and orally active oestrogen receptor (ER) modulator (SERM), exhibits potent antagonist activity at ERα and ERβ. Y134 shows 121.1-fold selectivity for ERα (Ki=0.09 nM) over ERβ (Ki=11.31 nM) . Y134 inhibits oestrogen-stimulated proliferation of ER-positive human breast cancer cells[1].
CAS Number
849662-80-2
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/y134.html
Purity
99.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(O)=CC=C31)C4=CC=C(N5CCN(C(C)C)CC5)C=C4
Molecular Formula
C28H28N2O3S
Molecular Weight
472.60
References & Citations
[1]Ning M, et, al. Biological activities of a novel selective oestrogen receptor modulator derived from raloxifene (Y134) . Br J Pharmacol. 2007 Jan;150 (1) :19-28.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα; ERβ

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