P-Selectin Glycoprotein Ligand-1/CD162 Extracellular Domain (human, Fc-tagged)

• Description:

  P-Selectin Glycoprotein Ligand-1/CD162 Extracellular Domain (human, Fc-tagged)_x000D_ Catalog number: B2016804_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 µg_x000D_ Molecular Weight or Concentration: 57.1 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: CD162, Cluster Of Differentiation 162, PSGL-1, Selectin P Ligand, SELPLG_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Xu J, Lasry JB, Svaren J, Wagner B, Darien BJ. Identification of equine P-selectin glycoprotein ligand-1 (CD162) Mamm Genome. 2005 Jan;16(1):66-71._x000D_ 2: Chen SC, Huang CC, Chien CL, Jeng CJ, Su HT, Chiang E, Liu MR, Wu CH, Chang CN, Lin RH. Cross-linking of P-selectin glycoprotein ligand-1 induces death of activated T cells Blood. 2004 Nov 15;104(10):3233-42._x000D_ 3: Nishimura Y, Shimizu H. [Identification of P-selectin glycoprotein ligand-1 as one of the cellular receptors for enterovirus 71] Uirusu. 2009 Dec;59(2):195-203._x000D_ 4: Ali AJ, Abuelela AF, Merzaban JS. An Analysis of Trafficking Receptors Shows that CD44 and P-Selectin Glycoprotein Ligand-1 Collectively Control the Migration of Activated Human T-Cells Front Immunol. 2017 May 3;8:492._x000D_ 5: Ma YQ, Plow EF, Geng JG. P-selectin binding to P-selectin glycoprotein ligand-1 induces an intermediate state of alphaMbeta2 activation and acts cooperatively with extracellular stimuli to support maximal adhesion of human neutrophils Blood. 2004 Oct 15;104(8):2549-56._x000D_ 6: Murakami T, Ono A. Roles of Virion-Incorporated CD162 (PSGL-1), CD43, and CD44 in HIV-1 Infection of T Cells Viruses. 2021 Sep 26;13(10):1935._x000D_ 7: Lo CY, Antonopoulos A, Gupta R, Qu J, Dell A, Haslam SM, Neelamegham S. Competition between core-2 GlcNAc-transferase and ST6GalNAc-transferase regulates the synthesis of the leukocyte selectin ligand on human P-selectin glycoprotein ligand-1 J Biol Chem. 2013 May 17;288(20):13974-13987._x000D_ 8: Kanabar V, Tedaldi L, Jiang J, Nie X, Panina I, Descroix K, Man F, Pitchford SC, Page CP, Wagner GK. Base-modified UDP-sugars reduce cell surface levels of P-selectin glycoprotein 1 (PSGL-1) on IL-1β-stimulated human monocytes Glycobiology. 2016 Oct;26(10):1059-1071._x000D_ 9: Xu T, Zhang L, Geng ZH, Wang HB, Wang JT, Chen M, Geng JG. P-selectin cross-links PSGL-1 and enhances neutrophil adhesion to fibrinogen and ICAM-1 in a Src kinase-dependent, but GPCR-independent mechanism Cell Adh Migr. 2007 Jul-Sep;1(3):115-23._x000D_ 10: Li L, Qian KX, Geng JG. A 28-kDa glycoprotein functions as a platelet ligand for P-selectin (CD62P) Thromb Haemost. 2002 Apr;87(4):706-11._x000D_ _x000D_ Products Related to P-Selectin Glycoprotein Ligand-1/CD162 Extracellular Domain (human, Fc-tagged) can be found at Proteins

• Short Description:

  Catalog Number: B2016804 (50 µg)_x000D_ P-Selectin Glycoprotein Ligand-1/CD162 Extracellular Domain (human, Fc-tagged) is a high quality P-Selectin Glycoprotein Ligand-1 (PSGL-1), also known as CD162, is a cell surface glycoprotein that plays a crucial role in mediating leukocyte rolling and adhesion to activated endothelial cells during inflammation. The extracellular domain of PSGL-1 is the part of the protein that interacts with selectins on endothelial cells._x000D_ _x000D_ In the context of a recombinant protein, the P-Selectin Glycoprotein Ligand-1/CD162 Extracellular Domain (human, Fc-tagged) refers to a protein construct that includes the extracellular domain of human PSGL-1 with an Fc tag attached. The Fc tag is a region derived from an antibody that can be used for purification and detection purposes._x000D_ _x000D_ This recombinant protein can be used in research to study the interactions between PSGL-1 and selectins, as well as to investigate the role of PSGL-1 in leukocyte adhesion and inflammation. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5