CD162 (Selectin P Ligand)

• Gene Name:

  [CD162]

• NCBI Gene ID:

  6404

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  CD162 glycoprotein functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response.

• Other Gene Names:

  [SELPLG; SELPLG; CLA; CD162; PSGL1; PSGL-1; PSGL-1]

• Short Name:

  [CD162]

• Other Product Names:

  [P-selectin glycoprotein ligand 1 isoform 1; P-selectin glycoprotein ligand 1; P-selectin glycoprotein ligand 1; selectin P ligand; Selectin P ligand]

• NCBI GI Number:

  331284238

• NCBI Accession Number:

  NP_001193538.1

• NCBI GB Accession Number:

  NP_001193538.1

• Uniprot Accession Number:

  Q14242