Thymidine-2′-13C

Thymidine-2′-13C

• CAS Number: 185553-96-2
• UNSPSC Description: Thymidine-2′-13C is the 13C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1]<
• Target Antigen: DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds; Orthopoxvirus
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Others
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/thymidine-2-13c.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N(C=C(C(N1)=O)C)[C@]2([H])O[C@@H]([C@H]([13CH2]2)O)CO
• Molecular Weight: 243.22
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Chen G, et al. Cell Synchronization by Double Thymidine Block. Bio Protoc. 2018 Sep 5;8(17).;FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181(4
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported