I-287

I-287

• CAS Number: 2014368-93-3
• UNSPSC Description: I-287 is a orally active selective PAR2 inhibitor that acting as a negative allosteric regulator on Gαq and Gα12/13 activity and their downstream effectors. I-287 reduces Complete Freund's adjuvant (HY-153808)-induced inflammation in mice and can be used for inflammation/immunology research[1].
• Target Antigen: ERK; Protease Activated Receptor (PAR)
• Type: Reference compound
• Related Pathways: GPCR/G Protein;MAPK/ERK Pathway;Stem Cell/Wnt
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/i-287.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(C1=CN=C(N2CCN(C(C)(C2)C)C(C3=CC(N=C(C4=CC=C(C(F)=C4)Cl)C=C5C(C)(C)C)=C5O3)=O)C=C1)O
• Molecular Weight: 565.04
• References & Citations: [1]Avet C, et.al. The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects. Commun Biol. 2020 Nov 27;3(1):719.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported