TPI-287

TPI-287

• CAS Number: 849213-15-6
• UNSPSC Description: TPI-287, a blood-brain barrier-permeable microtubule stabilizer, can significantly reduce metastatic colonization of breast cancer in the brain[1].
• Target Antigen: Microtubule/Tubulin
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tpi-287.html
• Purity: 99.47
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: CC1(C)[C@@]2(O)C[C@H](OC([C@H](O)[C@@H](NC(OC(C)(C)C)=O)CC(C)C)=O)C(C)=C1[C@]([H])(OC(C)=O)[C@@]3([H])[C@@]4(C)[C@]([C@@](CO5)(OC(C)=O)[C@@]5([H])C[C@]4([H])OC(C=C)O3)([H])[C@@H]2OC(C6=CC=CC=C6)=O
• Molecular Weight: 869.99
• References & Citations: [1]Daniel P Fitzgerald, et al. TPI-287, a new taxane family member, reduces the brain metastatic colonization of breast cancer cells. Mol Cancer Ther. 2012 Sep;11(9):1959-67.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, stored under nitrogen)
• Clinical Information: Phase 2