Piperacillin (sodium)

• UNSPSC Description:

  Piperacillin sodium is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin is most commonly used in combination with the β-lactamase inhibitor Tazobactam[1][2][3].

• Target Antigen:

  Antibiotic; Bacterial; Penicillin-binding protein (PBP)

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Piperacillin-sodium.html

• Purity:

  98.01

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 100 mg/mL

• Smiles:

  O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC([C@H](NC(N3C(C(N(CC)CC3)=O)=O)=O)C4=CC=CC=C4)=O)N1C2=O)O[Na]

• Molecular Weight:

  539.54

• References & Citations:

  [1]Tan JS, et al. Antipseudomonal penicillins. Med Clin North Am. 1995 Jul;79(4):679-93.|[2]Lau WK, et al. Randomized, open-label, comparative study of piperacillin-tazobactam administered by continuous infusion versus intermittent infusion for treatment of hospitalized patients with complicated intra-abdominal infection. Antimicrob Agents Chemother. 2006 Nov;50(11):3556-61.|[3]Fu KP, et al. Piperacillin, a new penicillin active against many bacteria resistant to other penicillins. Antimicrob Agents Chemother. 1978 Mar;13(3):358-67.|[4]Fu KP, et al. Piperacillin, a new penicillin active against many bacteria resistant to other penicillins. Antimicrob Agents Chemother. 1978，13(3):358-67.|[5]Bodey GP, et al. Piperacillin: In Vitro Evaluation. Antimicrob Agents Chemother. 1978，14(1):78-87.|[6]Harada Y, et al. In vitro and in vivo activities of piperacillin-tazobactam and meropenem at different inoculum sizes of ESBL-producing Klebsiella pneumoniae. Clin Microbiol Infect. 2014，20(11):O831-9.Biomed Res Int. 2018 Jul 2;2018:3579832. |bioRxiv. 2024 May 10.|Nat Commun. 2022 Mar 2;13(1):1116.|Antimicrob Agents Chemother. 2023 May 18;e0160322.|Microbiol Spectr. 2022 Dec 8;e0303822.|Microbiol Spectr. 2023 Apr 24;e0069223.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  59703-84-3