Piperacillin

• Description:

  Piperacillin is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin is most commonly used in combination with the β-lactamase inhibitor Tazobactam[1][2][3].

• Product Name Alternative:

  Pipracil

• UNSPSC:

  12352005

• Hazard Statement:

  H317, H334

• Target:

  Antibiotic; Bacterial; Beta-lactamase; Penicillin-binding protein (PBP)

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/piperacillin.html

• Concentration:

  10mM

• Purity:

  98.37

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C ([C@@H] (C (C) (C) S[C@]1 ([H]) [C@@H]2NC ([C@H] (NC (N3C (C (N (CC) CC3) =O) =O) =O) C4=CC=CC=C4) =O) N1C2=O) O

• Molecular Formula:

  C23H27N5O7S

• Molecular Weight:

  517.55

• Precautions:

  H317, H334

• References & Citations:

  [1]Fu KP, et al. Piperacillin, a new penicillin active against many bacteria resistant to other penicillins. Antimicrob Agents Chemother. 1978, 13 (3) :358-67. |[2]Bodey GP, et al. Piperacillin: In Vitro Evaluation. Antimicrob Agents Chemother. 1978, 14 (1) :78-87.|[3]Harada Y, et al. In vitro and in vivo activities of piperacillin-tazobactam and meropenem at different inoculum sizes of ESBL-producing Klebsiella pneumoniae. Clin Microbiol Infect. 2014, 20 (11) :O831-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  β-lactam

• Citation 01:

  Antimicrob Agents Chemother. 2023 Jun 15;67 (6) :e0160322.|Int J Antimicrob Agents. 2025 Jun 9:107551.|J Antimicrob Chemother. 2025 Nov 5:dkaf408.|medRxiv. 2025 Mar 13:2025.03.11.25323422.|Microbiol Spectr. 2023 Feb 14;11 (1) :e0303822.|Microbiol Spectr. 2023 Jun 15;11 (3) :e0069223.|Molecules. 2025 Mar 9;30 (6) :1224.|PLoS Pathog. 2024 Dec 31;20 (12) :e1012783.|Biomed Res Int. 2018 Jul 2:2018:3579832.|bioRxiv. 2024 May 10.|Nat Commun. 2022 Mar 2;13 (1) :1116.

• CAS Number:

  61477-96-1