GB-110 (hydrochloride)

GB-110 (hydrochloride)

• UNSPSC Description: GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM[1].
• Target Antigen: Protease Activated Receptor (PAR)
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/gb-110-hydrochloride.html
• Purity: 99.86
• Solubility: DMSO : 125 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic)
• Smiles: O=C(C1=CC=NO1)N[C@@H](CC2CCCCC2)C(N[C@@H]([C@@H](C)CC)C(NCC3=CC=CC(C(N4CCC(CN)CC4)=O)=C3)=O)=O.Cl
• Molecular Weight: 645.23
• References & Citations: [1]Barry GD, et al. Novel agonists and antagonists for human protease activated receptor 2. J Med Chem. 2010 Oct 28;53(20):7428-40.|[2]Suen JY, et al. Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110). Br J Pharmacol. 2012 Mar;165(5):1413-23.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported