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Icapamespib (hydrochloride)

CAT: 0804-HY-137441A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137441A-01Size:5 mg
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Description
Icapamespib (PU-HZ151; PU-AD) hydrochloride is a selective, orally active inhibitor of Epichaperomes assembled by HSP90 with slow dissociation kinetics. Icapamespib hydrochloride can cross the blood-brain barrier (BBB) ??and induce epichaperome disassembly by non-covalently binding to HSP90, restoring the normal protein-protein interaction network. Icapamespib hydrochloride can specifically disrupt disease-related abnormal protein interaction networks, reduce neurotoxic protein aggregation and tumor cell survival signals. Icapamespib hydrochloride can be used in the research of neurodegenerative diseases such as Alzheimer's disease, as well as cancers such as glioblastoma and metastatic breast cancer[1][2][3].
CAS Number
2267287-26-1
Product Name Alternative
PU-HZ151 (hydrochloride)
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/icapamespib-hydrochloride.html
Purity
98.67
Solubility
H2O : 9.09 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
IC1=C(SC2=NC3=C(N2CCNCC(C)(C)C)N=CN=C3N)C=C4OCOC4=C1.Cl.Cl
Molecular Formula
C19H25Cl2IN6O2S
Molecular Weight
599.32
References & Citations
[1]Bolaender A, et al. Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system. Nat Commun. 2021;12 (1) :4669. Published 2021 Aug 3.|[2]Pasala C, et al. Epichaperomes: redefining chaperone biology and therapeutic strategies in complex diseases. RSC Chem Biol. 2025 Mar 19;6 (5) :678-698.|[3]Bay S, et al. Synthesis and Characterization of Click Chemical Probes for Single-Cell Resolution Detection of Epichaperomes in Neurodegenerative Disorders. Biomedicines. 2024 Jun 4;12 (6) :1252.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
HSP90

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