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Icapamespib HCl

CAT: 0931-T69712-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T69712-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2267287-26-1
Target
HSP, Others
Related Pathways
Others, Cytoskeletal Signaling, Metabolism
Bioactivity
Icapamespib, also known as PU-HZ 151, is a heat shock protein 90 (HSP90) inhibitor. PU-HZ151 showed EC50 of 5 nM in the FP assay as compared to 11 nM for PU-H71 and a logD of 2.37 as compared to 1.21 for PU-H71. PU-HZ151 and radiolabeled PU-HZ151 showed selectivity for epichaperomes over the individual chaperome members. Icapamespib demonstrated the ability to productively engage the target in cells, mice, and humans.
Smiles
Cl.Cl.CC(C)(C)CNCCn1c(Sc2cc3OCOc3cc2I)nc2c(N)ncnc12
Molecular Formula
C19H25Cl2IN6O2S
Molecular Weight
599.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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HY-137441-01Icapamespib
HY-137441A-01Icapamespib (hydrochloride)
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