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Barnidipine (hydrochloride)

CAT: 0804-HY-107322-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107322-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Barnidipine (Mepirodipine) hydrochloride is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki = 0.21 nmol/L, has selective action against CaA receptors. Barnidipine hydrochloride is an orally active antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance[1][2][3][4].
CAS Number
104757-53-1
Product Name Alternative
Mepirodipine (hydrochloride) ; YM-09730-5
UNSPSC
12352005
Hazard Statement
H317, H319
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/barnidipine-hydrochloride.html
Purity
99.94
Solubility
DMSO : 233.33 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC([N+]([O-])=O)=CC=C2)O[C@@H]3CN(CC4=CC=CC=C4)CC3.[H]Cl
Molecular Formula
C27H30ClN3O6
Molecular Weight
528.00
Precautions
H317, H319
References & Citations
[1]van Zwieten PA, et al. Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist. Blood Press Suppl. 1998;1:5-8.|[2]Malhotra HS, et al. Barnidipine. Drugs. 2001;61 (7) :989-96; discussion 997-8.|[3]Teramura T, et al. Pharmacokinetics of barnidipine hydrochloride, a new dihydropyridine calcium channel blocker, in the rat, dog and human. Xenobiotica. 1995 Nov;25 (11) :1237-46.|[4]Hashimoto M, et al. Treatment with a Ca (2+) channel blocker, barnidipine, reduces platelet-derived growth factor B-chain mRNA in glomeruli of spontaneously hypertensive rats. Am J Nephrol. 1999;19 (5) :615-21.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
L-type calcium channel

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