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Barnidipine

CAT: 0804-HY-107322A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107322A-01Size:5 mg
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Description
Barnidipine (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki = 0.21 nmol/L), has selective action against CaA receptors. Barnidipine is an orally effective antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance[1][2][3].
CAS Number
104713-75-9
Product Name Alternative
Mepirodipine; YM-09730-5 (Free base)
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/barnidipine.html
Purity
98.97
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C)NC(C)=C(C(O[C@@H]2CN(CC3=CC=CC=C3)CC2)=O)[C@H]1C4=CC=CC([N+]([O-])=O)=C4)OC
Molecular Formula
C27H29N3O6
Molecular Weight
491.54
References & Citations
[1]van Zwieten PA, et al. Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist. Blood Press Suppl. 1998;1:5-8|[2]Malhotra HS, et al. Barnidipine. Drugs. 2001;61 (7) :989-96; discussion 997-8.|[3]Hashimoto M, et al. Treatment with a Ca (2+) channel blocker, barnidipine, reduces platelet-derived growth factor B-chain mRNA in glomeruli of spontaneously hypertensive rats. Am J Nephrol. 1999;19 (5) :615-21.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
L-type calcium channel

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MBS5752198Barnidipine
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A21940-100Barnidipine 100mg
A21940-50Barnidipine 50mg
A21940-10Barnidipine 10mg
A21940-1Barnidipine 1mg

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