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Pseudocoptisine (acetate)

CAT: 0804-HY-N6894Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N6894Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pseudocoptisine (Isocoptisine) acetate is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine acetate inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects[1][2].
CAS Number
30426-66-5
Product Name Alternative
Isocoptisine (acetate)
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Natural Products
Related Pathways
Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pseudocoptisine-acetate.html
Solubility
10 mM in DMSO
Smiles
CC([O-])=O.C12=[N+](C=C3C(C=C4C(OCO4)=C3)=C2)CCC5=CC6=C(OCO6)C=C15
Molecular Formula
C21H17NO6
Molecular Weight
379.36
References & Citations
[1]Yun KJ, et al. Quaternary alkaloid, pseudocoptisine isolated from tubers of Corydalis turtschaninovi inhibits LPS-induced nitric oxide, PGE (2), and pro-inflammatory cytokines production via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage cells. Int Immunopharmacol. 2009 Oct;9 (11) :1323-31.|[2]Hung TM, et al. Anti-amnestic activity of pseudocoptisine from Corydalis Tuber. Biol Pharm Bull. 2008;31 (1) :159-162.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE

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