Pseudocoptisine (chloride)

• UNSPSC Description:

  Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects[1][2].

• Target Antigen:

  Cholinesterase (ChE)

• Type:

  Natural Products

• Related Pathways:

  Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/pseudocoptisine-chloride.html

• Purity:

  99.36

• Solubility:

  DMSO : 1 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  C12=[N+](C=C3C(C=C4C(OCO4)=C3)=C2)CCC5=CC6=C(OCO6)C=C15.[Cl-]

• Molecular Weight:

  355.77

• References & Citations:

  [1]Hung TM, et al. Anti-amnestic activity of pseudocoptisine from Corydalis Tuber. Biol Pharm Bull. 2008;31(1):159-162.|[2]Yun KJ, et al. Quaternary alkaloid, pseudocoptisine isolated from tubers of Corydalis turtschaninovi inhibits LPS-induced nitric oxide, PGE(2), and pro-inflammatory cytokines production via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage cells. Int Immunopharmacol. 2009;9(11):1323-1331.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  30044-78-1