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Artobiloxanthone

CAT: 0804-HY-N12960Size: InquireDry Ice: NoHazardous: No
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CAT#:0804-HY-N12960Size:Inquire
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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UNSPSC Description
Artobiloxanthone (Compound AA3) exhibits antitumor activity, particularly against oral squamous cell carcinoma (OSCC). Artobiloxanthone inhibits Akt/mTOR pathway and STAT3 pathway, inhibits proliferation of SAS and T.Tn (with IC50 of 11 and 22 μM), and inhibits the cancer cell migration. Artobiloxanthone arrests cell cycle at S phase, and induces apoptosis in OSCC cells through activation of caspase 3/9[1].
Target Antigen
Apoptosis; Bcl-2 Family; Caspase; COX; MMP; STAT
Type
Natural Products
Related Pathways
Apoptosis;Immunology/Inflammation;JAK/STAT Signaling;Metabolic Enzyme/Protease;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/artobiloxanthone.html
Smiles
C=C(C1CC2=C(C3=C(C=C(C(O)=C31)O)O)OC4=C5C=CC(C)(OC5=CC(O)=C4C2=O)C)C
Molecular Weight
434.44
References & Citations
[1]Aswathy M, et al., Natural Prenylflavones from the Stem Bark of Artocarpus altilis: Promising Anticancer Agents for Oral Squamous Cell Carcinoma Targeting the Akt/mTOR/STAT-3 Signaling Pathway. ACS Omega. 2024 May 24;9(23):24252-24267.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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CatalogName
GTR19265997-01Artobiloxanthone

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