YL-5092

• Description:

  YL-5092 is a selective YT521-B homology (YTH) domain-containing protein 1 (YTHDC1) inhibitor with an IC50 of 7.4 nM and a KD of 29.6 nM. YL-5092 can suppress cancer cell proliferation and induce cell G0/G1 phase arrest and apoptosis. YL-5092 can be used for the research of cancer, such as acute myeloid leukemia (AML) [1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/yl-5092.html

• Purity:

  99.83

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (C1=CNC (C (NC2=CC=C (C3=CN=CS3) C=C2) =O) =C1) C4=C (C (F) (F) F) C=CC=C4

• Molecular Formula:

  C22H14F3N3O2S

• Molecular Weight:

  441.43

• References & Citations:

  [1]Yang S, et al. Discovery of a selective YTHDC1 inhibitor that targets acute myeloid leukemia[J]. 2023.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  3056857-07-6