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YL-5092

CAT: 0804-HY-164607-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-164607-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YL-5092 is a selective YT521-B homology (YTH) domain-containing protein 1 (YTHDC1) inhibitor with an IC50 of 7.4 nM and a KD of 29.6 nM. YL-5092 can suppress cancer cell proliferation and induce cell G0/G1 phase arrest and apoptosis. YL-5092 can be used for the research of cancer, such as acute myeloid leukemia (AML) [1].
CAS Number
3056857-07-6
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yl-5092.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CNC(C(NC2=CC=C(C3=CN=CS3)C=C2)=O)=C1)C4=C(C(F)(F)F)C=CC=C4
Molecular Formula
C22H14F3N3O2S
Molecular Weight
441.43
References & Citations
[1]Yang S, et al. Discovery of a selective YTHDC1 inhibitor that targets acute myeloid leukemia[J]. 2023.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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