YL-1-9

• Description :

  YL-1-9 is an inhibitor of the degradation of p53 by MDM2 through strong binding to the key hydrophobic pockets of MDM2. YL-1-9 induces cell cycle arrest and apoptosis in breast cancer cells[1].

• CAS Number :

  [3064304-12-4]

• UNSPSC :

  12352005

• Target :

  Apoptosis; CDK; MDM-2/p53

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Smiles :

  O=C(NC1=CC(C(F)(F)F)=C(CN2CCC(C)CC2)C=C1)C3=CC(OCO4)=C4C=C3

• Molecular Formula :

  C22H23F3N2O3

• Molecular Weight :

  420.42

• References & Citations :

  [1]Chongyun Zhou, et al. The novel Piperine derivative YL-1-9 exhibits anti-breast Cancer effects by inducing apoptosis via the p53/p21 pathway. Bioorg Med Chem Lett. 2025 Aug 1:123:130231.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported