Products for Research Use Only
RegisterLogin

Istaroxime (hydrochloride)

CAT: 0804-HY-15718A-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-15718A-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Istaroxime hydrochloride is a Na+/K+-ATPase inhibitor (IC50=0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.
CAS Number
374559-48-5
Product Name Alternative
PST2744 (hydrochloride)
UNSPSC
12352211
Target
Calcium Channel; Na+/K+ ATPase
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Istaroxime-hydrochloride.html
Purity
99.32
Solubility
DMSO : ≥ 45 mg/mL|H2O : 25 mg/mL (ultrasonic)
Smiles
O=C1CC[C@@]2([H])[C@]3([H])CC([C@@]4([H])C/C(CC[C@]4(C)[C@@]3([H])CC[C@@]21C)=N/OCCN)=O.[H]Cl
Molecular Formula
C21H33ClN2O3
Molecular Weight
396.95
References & Citations
[1]Gobbini M, et al. Novel analogues of istaroxime, a potent inhibitor of Na+, K+-ATPase: synthesis and structure-activity relationship. J Med Chem. 2008 Aug 14;51 (15) :4601-8.|[2]Gobbini M, et al. Novel analogues of Istaroxime, a potent inhibitor of Na (+), K (+) -ATPase: Synthesis, structure-activity relationship and 3D-quantitative structure-activity relationship of derivatives at position 6 on the androstane scaffold. Bioorg Med Ch|[3]Micheletti R, et al. Pharmacological profile of the novel inotropic agent (E, Z) -3- ((2-aminoethoxy) imino) androstane-6,17-dione hydrochloride (PST2744) . J Pharmacol Exp Ther. 2002 Nov;303 (2) :592-600.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Citation 01
Biochem Pharmacol. 2020 Oct;180:114122.|Biochem Pharmacol. 2023 May:211:115516.|Front Pharmacol. 2020 Dec 14:11:606097.|J Am Heart Assoc. 2021 Jul 20;10 (14) :e018833.|Nat Commun. 2025 Aug 29;16 (1) :8074.|PNAS Nexus. 2023 Dec 22;3 (1) :pgad453.

Related Products

CatalogName
HY-15718Istaroxime
HY-15718BIstaroxime (oxalate)
HY-B0500BAlverine (hydrochloride)
HY-W714513VU0469650 (hydrochloride)
HY-W708286-01α-Pyrrolidinobutiothiophenone (hydrochloride)
HY-W492795Quifenadine (hydrochloride)
HY-W012179-01Phenylpiperazine (hydrochloride)
HY-Z6449-01Phenylephrone (hydrochloride)
HY-W209279(±) Anabasine (hydrochloride)
HY-W027446-01Pyridoxal hydrochloride

Alternative Products

CatalogName
DIA73793-01Istaroxime hydrochloride
A13041-50Istaroxime hydrochloride 50mg
A13041-10Istaroxime hydrochloride 10mg
A13041-25Istaroxime hydrochloride 25mg
A13041-5Istaroxime hydrochloride 5mg
A13041-2Istaroxime hydrochloride (PST2744 hydrochloride) 2mg
A13041-100Istaroxime hydrochloride (PST2744 hydrochloride) 100mg
A13041-10mM-DIstaroxime hydrochloride (PST2744 hydrochloride) 10mM * 1mL in DMSO
A3507-2Istaroxime
563726Istaroxime HCl

Popular Products