Istaroxime

• Description:

  Istaroxime (PST2744) is a potent inhibitor of Na+, K+-ATPase with IC50 of 0.11 μM.

• Product Name Alternative:

  PST2744

• UNSPSC:

  12352211

• Target:

  Na+/K+ ATPase

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Istaroxime.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1CC[C@@]2 ([H]) [C@]3 ([H]) CC ([C@@]4 ([H]) C/C (CC[C@]4 (C) [C@@]3 ([H]) CC[C@@]21C) =N/OCCN) =O

• Molecular Formula:

  C21H32N2O3

• Molecular Weight:

  360.49

• References & Citations:

  [1]Gobbini M, et al. Novel analogues of istaroxime, a potent inhibitor of Na+, K+-ATPase: synthesis and structure-activity relationship. J Med Chem. 2008 Aug 14;51 (15) :4601-8.|[2]Gobbini M, et al. Novel analogues of Istaroxime, a potent inhibitor of Na (+), K (+) -ATPase: Synthesis, structure-activity relationship and 3D-quantitative structure-activity relationship of derivatives at position 6 on the androstane scaffold. Bioorg Med Ch|[3]Micheletti R, et al. Pharmacological profile of the novel inotropic agent (E, Z) -3- ((2-aminoethoxy) imino) androstane-6,17-dione hydrochloride (PST2744) . J Pharmacol Exp Ther. 2002 Nov;303 (2) :592-600.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Citation 01:

  Nat Commun. 2025 Aug 29;16 (1) :8074.|PNAS Nexus. 2023 Dec 22;3 (1) :pgad453.|Biochem Pharmacol. 2020 Oct;180:114122.|Biochem Pharmacol. 2023 May:211:115516.|Front Pharmacol. 2020 Dec 14:11:606097.|J Am Heart Assoc. 2021 Jul 20;10 (14) :e018833.

• CAS Number:

  203737-93-3