Istaroxime

• Description :

  Istaroxime (PST2744) is a potent inhibitor of Na+, K+-ATPase with IC50 of 0.11 μM.

• Product Name Alternative :

  PST2744

• UNSPSC :

  12352211

• Target :

  Na+/K+ ATPase

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/Istaroxime.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1CC[C@@]2([H])[C@]3([H])CC([C@@]4([H])C/C(CC[C@]4(C)[C@@]3([H])CC[C@@]21C)=N/OCCN)=O

• Molecular Formula :

  C21H32N2O3

• Molecular Weight :

  360.49

• References & Citations :

  [1]Gobbini M, et al. Novel analogues of istaroxime, a potent inhibitor of Na+, K+-ATPase: synthesis and structure-activity relationship. J Med Chem. 2008 Aug 14;51 (15) :4601-8.|[2]Gobbini M, et al. Novel analogues of Istaroxime, a potent inhibitor of Na (+), K (+) -ATPase: Synthesis, structure-activity relationship and 3D-quantitative structure-activity relationship of derivatives at position 6 on the androstane scaffold. Bioorg Med Ch|[3]Micheletti R, et al. Pharmacological profile of the novel inotropic agent (E, Z) -3- ((2-aminoethoxy) imino) androstane-6,17-dione hydrochloride (PST2744) . J Pharmacol Exp Ther. 2002 Nov;303 (2) :592-600.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Citation 01 :

  Nat Commun. 2025 Aug 29;16 (1) :8074.|PNAS Nexus. 2023 Dec 22;3 (1) :pgad453.|Biochem Pharmacol. 2020 Oct;180:114122.|Biochem Pharmacol. 2023 May:211:115516.|Front Pharmacol. 2020 Dec 14:11:606097.|J Am Heart Assoc. 2021 Jul 20;10 (14) :e018833.

• CAS Number :

  [203737-93-3]