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ATB 429

CAT: 0931-T210332-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T210332-01Size:10 mg
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CAS Number
915798-75-3
Target
Endogenous Metabolite
Related Pathways
Metabolism
Bioactivity
ATB-429 is a mesalazine derivative capable of releasing H2S, demonstrating significant analgesic and anti-inflammatory effects in an irritable bowel syndrome (IBS) model. By releasing hydrogen sulfide (H2S), ATB-429 modulates hypersensitivity induced by colorectal distension in healthy and post-colitis rats. It alleviates abdominal withdrawal responses and inhibits spinal c-Fos mRNA expression, indicating its potential to relieve pain associated with gastrointestinal inflammation. Furthermore, ATB-429 downregulates mRNA expression of colonic cyclooxygenase-2 (COX-2) and IL-1?, an effect not observed with mesalazine alone. The mechanism involves ATP-sensitive K+ (KATP) channels, evidenced by the reversal of ATB-429's effects with glibenclamide. These findings suggest that ATB-429 may offer therapeutic benefits for treating inflammatory pain-related bowel conditions.
Smiles
O=C(OC=1C=CC(=CC1)C2=CSSC2=S)C3=CC(N)=CC=C3O
Molecular Formula
C16H11NO3S3
Molecular Weight
361.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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