SGC-CK2-1
CAT:
804-HY-139004-06
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
SGC-CK2-1
- CAS Number: 2470424-39-4
- UNSPSC Description: SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC50s of 36 and 16 nM for CK2α and CK2α′respectively in the nanoBRET assay. SGC-CK2-1 can be used for the research of neurodegenerative diseases[1][2].
- Target Antigen: Casein Kinase
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Stem Cell/Wnt
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/sgc-ck2-1.html
- Smiles: CCC(NC1=CC(NC2=NC3=C(C#N)C=NN3C(NC4CC4)=C2)=CC=C1C)=O
- Molecular Weight: 375.43
- References & Citations: [1]Carrow I Wells, et al. Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chem Biol. 2021 Apr 15;28(4):546-558.e10.|[2]Marco P Licciardello, et al. A New Chemical Probe Challenges the Broad Cancer Essentiality of CK2. Trends Pharmacol Sci. 2021 May;42(5):313-315.
- Shipping Conditions: Room Temperature