SGC-AAK1-1
CAT:
804-HY-123940-01
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
SGC-AAK1-1
- CAS Number: 2247894-32-0
- UNSPSC Description: SGC-AAK1-1 is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC50 of 270 nM and a Ki of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1[1].
- Target Antigen: AAK1
- Type: Reference compound
- Related Pathways: Neuronal Signaling
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/sgc-aak1-1.html
- Purity: 98.93
- Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: O=C(C1CC1)NC2=NNC3=C2C=CC(C4=CC=CC(NS(=O)(N(CC)CC)=O)=C4)=C3
- Molecular Weight: 427.52
- References & Citations: [1]Agajanian MJ, et al. WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Rep. 2019 Jan 2;26(1):79-93.e8.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported