7-Ketocholesterol

• Description :

  7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis) [1].

• Product Name Alternative :

  CI-636, Clodantoin, Xenazoic acid; CV58911

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Endogenous Metabolite; p38 MAPK

• Type :

  Natural Products

• Related Pathways :

  MAPK/ERK Pathway; Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/7-ketocholesterol.html

• Purity :

  99.87

• Solubility :

  DMSO : 6.06 mg/mL (ultrasonic)

• Smiles :

  C[C@]1(CC2)[C@](CC[C@]1([H])[C@H](C)CCCC(C)C)([H])[C@@](C(C=C3C[C@H]4O)=O)([H])[C@@]2([H])[C@]3(CC4)C

• Molecular Formula :

  C27H44O2

• Molecular Weight :

  400.64

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]M A Lyons, et al. 7-Ketocholesterol. Int J Biochem Cell Biol. Mar-Apr 1999;31 (3-4) :369-75. |[2]Amelia Anderson, et al. 7-Ketocholesterol in disease and aging. Redox Biol. 2020 Jan;29:101380.|[3]Amaral J, et al. 7-Ketocholesterol induces inflammation and angiogenesis in vivo: a novel rat model. PLoS One. 2013;8 (2) :e56099.|[4]Tani M, et al. 7-Ketocholesterol enhances leukocyte adhesion to endothelial cells via p38MAPK pathway. PLoS One. 2018 Jul 31;13 (7) :e0200499.|[5]Luthra S, et al. 7-Ketocholesterol activates caspases-3/7, -8, and-12 in human microvascular endothelial cells in vitro[J]. Microvascular research, 2008, 75 (3) : 343-350.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Human Endogenous Metabolite

• CAS Number :

  [566-28-9]