7-Ketocholesterol

CAT: 0804-HY-113342-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-113342-01Size:5 mg
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Description
7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis) [1].
CAS Number
[566-28-9]
Product Name Alternative
CI-636, Clodantoin, Xenazoic acid; CV58911
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; p38 MAPK
Type
Natural Products
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/7-ketocholesterol.html
Purity
99.87
Solubility
DMSO : 6.06 mg/mL (ultrasonic)
Smiles
C[C@]1(CC2)[C@](CC[C@]1([H])[C@H](C)CCCC(C)C)([H])[C@@](C(C=C3C[C@H]4O)=O)([H])[C@@]2([H])[C@]3(CC4)C
Molecular Formula
C27H44O2
Molecular Weight
400.64
Precautions
H302, H315, H319, H335
References & Citations
[1]M A Lyons, et al. 7-Ketocholesterol. Int J Biochem Cell Biol. Mar-Apr 1999;31 (3-4) :369-75. |[2]Amelia Anderson, et al. 7-Ketocholesterol in disease and aging. Redox Biol. 2020 Jan;29:101380.|[3]Amaral J, et al. 7-Ketocholesterol induces inflammation and angiogenesis in vivo: a novel rat model. PLoS One. 2013;8 (2) :e56099.|[4]Tani M, et al. 7-Ketocholesterol enhances leukocyte adhesion to endothelial cells via p38MAPK pathway. PLoS One. 2018 Jul 31;13 (7) :e0200499.|[5]Luthra S, et al. 7-Ketocholesterol activates caspases-3/7, -8, and-12 in human microvascular endothelial cells in vitro[J]. Microvascular research, 2008, 75 (3) : 343-350.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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