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Metarrestin

CAT: 0804-HY-120118-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120118-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Metarrestin (ML246) is an orally active, first-in-class and specific perinucleolar compartment inhibitor. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. Metarrestin blocks metastatic development and extends survival in mouse cancer models[1][2].
CAS Number
1443414-10-5
Product Name Alternative
ML246
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/metarrestin.html
Purity
99.90
Solubility
DMSO : 31.25 mg/mL (ultrasonic)
Smiles
O[C@H]1CC[C@H](N(C=NC2=C3C(C4=CC=CC=C4)=C(C5=CC=CC=C5)N2CC6=CC=CC=C6)C3=N)CC1
Molecular Formula
C31H30N4O
Molecular Weight
474.60
Precautions
H315, H319, H320
References & Citations
[1]Vilimas T, et al. Pharmacokinetic evaluation of the perinucleolar compartment disassembler metarrestin in wild-type and Pdx1-Cre; LSL-KrasG12D/+; Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer. Cancer Chemother Pharmacol. 2018 Dec;82 (6) :1067-1080.|[2]Frankowski KJ, et al. Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis. Sci Transl Med. 2018 May 16;10 (441) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

Alternative Products

CatalogName
T12006-01Metarrestin
A18795-100Metarrestin 100mg
A18795-5Metarrestin 5mg
A18795-25Metarrestin 25mg
A18795-1Metarrestin 1mg
A18795-500Metarrestin 500mg
A18795-50Metarrestin 50mg
A18795-10Metarrestin 10mg

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