Hydroxy bosentan

• Description :

  Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities[1].

• Product Name Alternative :

  Ro 48-5033

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Endogenous Metabolite

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/hydroxy-bosentan.html

• Purity :

  98.0

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=CC=CC=C1OC2=C(N=C(N=C2OCCO)C3=NC=CC=N3)NS(C4=CC=C(C=C4)C(CO)(C)C)(=O)=O

• Molecular Formula :

  C27H29N5O7S

• Molecular Weight :

  567.61

• Precautions :

  P264-P270-P330-P501

• References & Citations :

  [1]Chen M, et al. Comparison of the inhibitory effect of ketoconazole, voriconazole, fluconazole, and itraconazoleon the pharmacokinetics of bosentan and its corresponding active metabolite hydroxy bosentanin rats. Xenobiotica. 2019 Jul 3:1-8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Human Endogenous Metabolite

• CAS Number :

  [253688-60-7]