Hydroxy bosentan

• Description:

  Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities[1].

• Product Name Alternative:

  Ro 48-5033

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/hydroxy-bosentan.html

• Purity:

  98.0

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC=CC=C1OC2=C (N=C (N=C2OCCO) C3=NC=CC=N3) NS (C4=CC=C (C=C4) C (CO) (C) C) (=O) =O

• Molecular Formula:

  C27H29N5O7S

• Molecular Weight:

  567.61

• Precautions:

  P264-P270-P330-P501

• References & Citations:

  [1]Chen M, et al. Comparison of the inhibitory effect of ketoconazole, voriconazole, fluconazole, and itraconazoleon the pharmacokinetics of bosentan and its corresponding active metabolite hydroxy bosentanin rats. Xenobiotica. 2019 Jul 3:1-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  253688-60-7