Ifosfamide

Ifosfamide

• CAS Number: 3778-73-2
• UNSPSC Description: Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors.
• Target Antigen: DNA Alkylator/Crosslinker
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ifosfamide.html
• Solubility: DMSO : ≥ 50 mg/mL
• Smiles: ClCCN1P(OCCC1)(NCCCl)=O
• Molecular Weight: 261.089
• References & Citations: [1]Helal M. Prenatal effects of transplacental exposure to ifosfamide in rats. Biotech Histochem. 2016 Jul;91(5):357-68.|[2]Karle P, et al. Necrotic, rather than apoptotic, cell death caused by cytochrome P450-activated ifosfamide. Cancer Gene Ther. 2001 Mar;8(3):220-30.|[3]Vredenburg G, et al. Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants. Toxicol Lett. 2015 Jan 5;232(1):182-92.
• Shipping Conditions: Room Temperature
• Clinical Information: Launched