PHTPP-1304

CAT: 0804-HY-161740-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-161740-01Size:1 mg
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Description
PHTPP-1304 is a PHTPP-based autophagy targeting chimera (AUTOTAC) . PHTPP-1304 induces the degradation of estrogen receptor ERβ through the autophagy pathway, rather than ubiquitination (DC50 ≈ 2 nM, in HEK293T cells; p62. PHTPP-1304 can be used to study various cancers mediated by ERβ[1].
CAS Number
[2410081-60-4]
UNSPSC
12352005
Target
Autophagy; AUTOTACs; Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Autophagy; PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/phtpp-1304.html
Purity
99.96
Solubility
DMSO : 110 mg/mL (ultrasonic)
Smiles
O[C@H](CNCCOCCOCCOC1=CC=C(C2=C3N(C(C(F)(F)F)=CC(C(F)(F)F)=N3)N=C2C4=CC=CC=C4)C=C1)COC5=CC(OCCCC6=CC=CC=C6)=C(OCC7=CC=CC=C7)C=C5
Molecular Formula
C51H50F6N4O7
Molecular Weight
944.96
References & Citations
[1]Ji CH, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13 (1) :904. doi: 10.1038/s41467-022-28520-4. Erratum in: Nat Commun. 2022 Apr 12;13 (1) :2108.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERβ

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