PHTPP-1304

CAT: 0931-T88793-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T88793-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2410081-60-4
Target
Estrogen Receptor/ERR|||Autophagy|||AUTACs
Related Pathways
Endocrinology/Hormones|||PROTAC|||Autophagy
Bioactivity
PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ER? (DC50: ~2 nM, HEK293T) . Additionally, PHTPP-1304 facilitates the formation of p62+ER?+ puncta in a dose-dependent manner, influencing autophagic flux.
Smiles
C(F)(F)(F)C=1N2C(=C(C(=N2)C3=CC=CC=C3)C4=CC=C(OCCOCCOCCNC[C@H](COC5=CC(OCCCC6=CC=CC=C6)=C(OCC7=CC=CC=C7)C=C5)O)C=C4)N=C(C(F)(F)F)C1
Molecular Formula
C51H50F6N4O7
Molecular Weight
944.96
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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Alternative Products

CatalogName
HY-161740-01PHTPP-1304
2662/10PHTPP
A17035-10PHTPP 10mg
A17035-25PHTPP 25mg
A17035-2PHTPP 2mg
A17035-5PHTPP 5mg
A17035-50PHTPP 50mg
A17035-100PHTPP 100mg
A17035-500PHTPP 500mg
HY-103456R-01PHTPP (Standard)

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