ISX-9

• Description:

  ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca2+ influx through both voltage-gated Ca2+ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs) [1][2][3].

• Product Name Alternative:

  Isoxazole 9

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Calcium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ISX-9.html

• Concentration:

  10mM

• Purity:

  99.19

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(C1=NOC(C2=CC=CS2)=C1)NC3CC3

• Molecular Formula:

  C11H10N2O2S

• Molecular Weight:

  234.27

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Petrik D, et al. Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule. FASEB J. 2012 Aug;26 (8) :3148-3162.|[2]Jay W Schneider, et al. Small-molecule activation of neuronal cell fate. Nat Chem Biol. 2008 Jul;4 (7) :408-10.|[3]Jamie L Russell, et al. Targeting native adult heart progenitors with cardiogenic small molecules. ACS Chem Biol. 2012 Jun 15;7 (6) :1067-76.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [832115-62-5]