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ISX-9

CAT: 0804-HY-12323-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12323-01Size:5 mg
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Description
ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca2+ influx through both voltage-gated Ca2+ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs) [1][2][3].
CAS Number
[832115-62-5]
Product Name Alternative
Isoxazole 9
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ISX-9.html
Concentration
10mM
Purity
99.19
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1=NOC(C2=CC=CS2)=C1)NC3CC3
Molecular Formula
C11H10N2O2S
Molecular Weight
234.27
Precautions
H315, H319, H335
References & Citations
[1]Petrik D, et al. Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule. FASEB J. 2012 Aug;26 (8) :3148-3162.|[2]Jay W Schneider, et al. Small-molecule activation of neuronal cell fate. Nat Chem Biol. 2008 Jul;4 (7) :408-10.|[3]Jamie L Russell, et al. Targeting native adult heart progenitors with cardiogenic small molecules. ACS Chem Biol. 2012 Jun 15;7 (6) :1067-76.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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