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L-Alanosine

CAT: 0804-HY-16933-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16933-01Size:1 mg
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Description
L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine is the inhibitor for methylthioadenosine phosphorylase (MTAP) [1][2][3].
CAS Number
5854-93-3
Product Name Alternative
NSC-153353; SDX-102
UNSPSC
12352211
Hazard Statement
H302
Target
Antibiotic; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/l-alanosine.html
Purity
99.85
Solubility
H2O : 15 mg/mL (ultrasonic; adjust pH to 8 with NaOH) |H2O : 50 mg/mL (ultrasonic)
Smiles
N[C@@H](CN(O)N=O)C(O)=O
Molecular Formula
C3H7N3O4
Molecular Weight
149.11
Precautions
H302
References & Citations
[1]Efferth T, et al. Identification of gene expression profiles predicting tumor cell response to L-alanosine. Biochem Pharmacol. 2003 Aug 15;66 (4) :613-21.|[2]Chitnis MP, et al. Antitumor effect of L-alanosine (NSC 153553) on sensitive and resistant sublines of murine leukemias. Tumori. 1984 Aug 31;70 (4) :317-20.|[3]Tyagi AK, et al. Identification of the antimetabolite of L-alanosine, L-alanosyl-5-amino-4-imidazolecarboxylic acid ribonucleotide, in tumors and assessment of its inhibition of adenylosuccinate synthetase. Cancer Res. 1980 Dec;40 (12) :4390-7.|[4]Singh SX, et al., Purine Synthesis Inhibitor L-Alanosine Impairs Mitochondrial Function and Stemness of Brain Tumor Initiating Cells. Biomedicines. 2022 Mar 23;10 (4) :751.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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