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α-Lipoic Acid-d5

CAT: 0804-HY-N0492SSize: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0492SSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
α-Lipoic Acid-d5 is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4].
CAS Number
1189471-66-6
Product Name Alternative
Thioctic acid-d5; (±) -α-Lipoic acid-d5; DL-α-Lipoic acid-d5
UNSPSC
12352005
Target
Apoptosis; Endogenous Metabolite; HIV; Isotope-Labeled Compounds; Mitochondrial Metabolism; NF-κB
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Cancer; Infection; Inflammation/Immunology
Purity
98.1
Solubility
10 mM in DMSO|DMSO : 100mg/mL (ultrasonic) |H2O : 0.1mg/mL (ultrasonic)
Smiles
OC(CCCC([2H])([2H])C1([2H])C([2H])([2H])CSS1)=O
Molecular Formula
C8H9D5O2S2
Molecular Weight
211.36
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Xiao L, et al. Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. Biofactors. 2006;27 (1-4) :157-65.; Yang Y, et al. Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. J Nutr Biochem. 2014 Nov;25 (11) :1207-1217.; Lei D, et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9 (15) :12137-12153.; Pibiri M, et al. α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells. Sci Rep. 2020 Apr 28;10 (1) :7139.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
HIV-1

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