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α-Lipoic Acid

CAT: 0804-HY-N0492-01Size: 500 mgDry Ice: NoHazardous: No
CAT#: HY-N0492-01Size: 500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4]. α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1[5].
CAS Number
[1077-28-7]
Product Name Alternative
Thioctic acid; (±) -α-Lipoic acid; DL-α-Lipoic acid
UNSPSC
12352005
Hazard Statement
H302, H315, H317, H319, H411
Target
Apoptosis; Endogenous Metabolite; HIV; Mitochondrial Metabolism; NF-κB
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/_alpha_-Lipoic-Acid.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
O=C(O)CCCCC1SSCC1
Molecular Formula
C8H14O2S2
Molecular Weight
206.33
Precautions
H302, H315, H317, H319, H411
References & Citations
[1]Xiao L, et al. Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. Biofactors. 2006;27 (1-4) :157-65.|[2]Yang Y, et al. Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. J Nutr Biochem. 2014 Nov;25 (11) :1207-1217.|[3]Lei D, et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9 (15) :12137-12153.|[4]Pibiri M, et al. α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells. Sci Rep. 2020 Apr 28;10 (1) :7139.|[5]Liu J, et al. Nanoaggregates of Disulfide-Decorated TrxR Inhibitor Promote Cellular Uptake, Selective Targeting, and Antitumor Efficacy. Langmuir, 2022.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
HIV-1; Human Endogenous Metabolite; NF-κB

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