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Pentoxifylline-d5

CAT: 0804-HY-B0715S2-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0715S2-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pentoxifylline-d5 is the deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation[1][2][3].
CAS Number
1185995-18-9
Product Name Alternative
BL-191-d5; PTX-d5; Oxpentifylline-d5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; HIV; Phosphodiesterase (PDE)
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Autophagy; Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease; Cancer
Purity
99.89
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1C2=C(N=CN2C)N(C(N1CCCC([2H])([2H])C(C([2H])([2H])[2H])=O)=O)C
Molecular Formula
C13H13D5N4O3
Molecular Weight
283.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Iffat Hassan, et al. Pentoxifylline and its applications in dermatology. Indian Dermatol Online J. 2014 Oct-Dec; 5 (4) : 510–516.|[3]A Ward, et al. Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs. 1987 Jul;34 (1) :50-97.|[4]Yessica Cristina Castellanos-Esparza, et al. Synergistic promoting effects of pentoxifylline and simvastatin on the apoptosis of triple-negative MDA-MB-231 breast cancer cells. Int J Oncol. 2018 Apr;52 (4) :1246-1254.|[5]Shabnam Movassaghi, et al. Effect of Pentoxifylline on Ischemia- induced Brain Damage and Spatial Memory Impairment in Rat. Iran J Basic Med Sci. 2012 Sep-Oct; 15 (5) : 1083-1090.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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