NF023 (hexasodium)

NF023 (hexasodium)

• CAS Number: 104869-31-0
• UNSPSC Description: NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively[1][2][3][4].
• Target Antigen: P2X Receptor
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/nf023-hexasodium.html
• Purity: 99.7
• Solubility: H2O : ≥ 116.3 mg/mL
• Smiles: O=C(C1=CC(NC(NC2=CC(C(NC(C(C([S](=O)(O[Na])=O)=C3)=C4C=C3[S](=O)(O[Na])=O)=CC=C4[S](=O)(O[Na])=O)=O)=CC=C2)=O)=CC=C1)NC(C(C([S](=O)(O[Na])=O)=C5)=C6C=C5[S](=O)(O[Na])=O)=CC=C6[S](=O)(O[Na])=O
• Molecular Weight: 1162.88
• References & Citations: [1]F Soto, et al. Antagonistic Properties of the Suramin Analogue NF023 at Heterologously Expressed P2X Receptors. Neuropharmacology. 1999 Jan;38(1):141-9.|[2]M Freissmuth, et al. Suramin Analogues as Subtype-Selective G Protein Inhibitors. Mol Pharmacol. 1996 Apr;49(4):602-11.|[3]G Lambrecht, et al. Agonists and Antagonists Acting at P2X Receptors: Selectivity Profiles and Functional Implications. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):340-50.|[4]M Silva-Ramos, et al. Activation of Prejunctional P2x2/3 Heterotrimers by ATP Enhances the Cholinergic Tone in Obstructed Human Urinary Bladders. J Pharmacol Exp Ther. 2020 Jan;372(1):63-72.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported