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NF023 (hexasodium)

CAT: 0804-HY-108676Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108676Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively[1][2][3][4].
CAS Number
104869-31-0
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nf023-hexasodium.html
Purity
99.99
Solubility
H2O : ≥ 116.3 mg/mL
Smiles
O=C(C1=CC(NC(NC2=CC(C(NC(C(C([S](=O)(O[Na])=O)=C3)=C4C=C3[S](=O)(O[Na])=O)=CC=C4[S](=O)(O[Na])=O)=O)=CC=C2)=O)=CC=C1)NC(C(C([S](=O)(O[Na])=O)=C5)=C6C=C5[S](=O)(O[Na])=O)=CC=C6[S](=O)(O[Na])=O
Molecular Formula
C35H20N4Na6O21S6
Molecular Weight
1162.88
Precautions
H315, H319, H335
References & Citations
[1]F Soto, et al. Antagonistic Properties of the Suramin Analogue NF023 at Heterologously Expressed P2X Receptors. Neuropharmacology. 1999 Jan;38 (1) :141-9.|[2]M Freissmuth, et al. Suramin Analogues as Subtype-Selective G Protein Inhibitors. Mol Pharmacol. 1996 Apr;49 (4) :602-11.|[3]G Lambrecht, et al. Agonists and Antagonists Acting at P2X Receptors: Selectivity Profiles and Functional Implications. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362 (4-5) :340-50.|[4]M Silva-Ramos, et al. Activation of Prejunctional P2x2/3 Heterotrimers by ATP Enhances the Cholinergic Tone in Obstructed Human Urinary Bladders. J Pharmacol Exp Ther. 2020 Jan;372 (1) :63-72.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X1 Receptor

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