α-Synuclein 4554W

• Description :

  α-Synuclein 4554W is an inhibitor of α-Synuclein (aSyn) aggregation with associated toxicity. α-Synuclein 4554W consists of GIVNGVKA sequences, previously identified through intracellular library screening. α-Synuclein 4554W reduces fibril formation of aSyn mutants assocaited with Parkinson’s disease[1].

• UNSPSC :

  12352209

• Target :

  α-synuclein

• Type :

  Peptides

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/α-synuclein-4554w.html

• Purity :

  99.53

• Solubility :

  H2O : ≥ 50 mg/mL

• Smiles :

  NC([C@H](C)NC([C@H](CCCCN)NC([C@H](C(C)C)NC(CNC([C@H](CC(N)=O)NC([C@H](C(C)C)NC([C@H]([C@@H](C)CC)NC(CNC([C@H](CC(O)=O)NC([C@@H](NC(C)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Formula :

  C45H80N14O14

• Molecular Weight :

  1041.20

• References & Citations :

  [1]Torpey J H, et al. Insights into peptide inhibition of alpha-synuclein aggregation[J]. Frontiers in Neuroscience, 2020, 14: 561462.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• Isoform :

  α-synuclein Aggregation

• CAS Number :

  [2243207-00-1]