Dyrk1A/α-synuclein-IN-1

• UNSPSC Description:

  Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual Dyrk1A and α-synuclein aggregation inhibitor with IC50 values of 177 nM and 10.5 µM, respectively. Dyrk1A/α-synuclein-IN-1 has high predictive CNS penetration and neuroprotective effect[1].

• Target Antigen:

  DYRK

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/dyrk1a-α-synuclein-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=NC2=C(S1)C=C(C=C2)O)NC3=CC=C(C=C3)NC(C4CCNCC4)=O

• Molecular Weight:

  411.48

• References & Citations:

  [1]AlNajjar, et al. Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects. European journal of medicinal chemistry 227 (2022): 113911.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2789711-47-1