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NCAO

CAT: 0804-HY-160843-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-160843-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
N-ω-chloroacetyl-L-ornithine (NCAO) is a potent reversible competitive ornithine decarboxylase (ODC) inhibitor that exerts cytotoxic and antiproliferative effects on tumor cell lines with EC50 values ranging from 1 to 50.6 µM. NCAO induces tumor cell Apoptosis and inhibits tumor cell migration in vitro. NCAO also exhibits a potent antitumor activity against both solid and ascitic tumors in a mouse model using the myeloma (Ag8) cell line. NCAO is promising for research of antitumor agents[1].
CAS Number
20584-81-0
UNSPSC
12352211
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ncao.html
Purity
98.07
Solubility
H2O : ≥ 100 mg/mL
Smiles
OC([C@@H](N)CCCNC(CCl)=O)=O
Molecular Formula
C7H13ClN2O3
Molecular Weight
208.64
References & Citations
[1]Vargas-Ramírez AL, et al. N-ω-chloroacetyl-L-ornithine has in-vitro activity against cancer cell lines and in-vivo activity against ascitic and solid tumors. Anticancer Drugs. 2016 Jul;27 (6) :508-18.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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