SLAMF7/CS1/CD319

SLAMF7/CS1/CD319

• Gene Name: [SLAMF7]
• NCBI Gene ID: 57823
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: CS1, also known as novel Ly9, SLAMF7, 19A24 or CRACC, is a homophilic cell surface receptor. It is a member of the SLAM (signaling lymphocytic activation molecule) family of receptors expressed on natural killer (NK) cells, T cells and stimulated B cells. CS1 contains immunoreceptor tyrosine-based switch motifs in its cytoplasmic domain but, unlike other SLAM receptors, it does not recruit SAP (SLAM-associated protein). In humans, CS1 activates NK cells through an EAT-2-mediated pathway that is SAP-independent. CS1 recruits and associates with EAT-2, a protein closely related to SAP. EAT-2 induces phosphorylation of CS1 which then, upon ligand binding, activates downstream cytotoxicity effectors PLC and PI 3K. In mice, the EAT-2 association with CS1 has an inhibitory effect on the activation of NK cells.
• Other Gene Names: [SLAMF7; SLAMF7; 19A; CS1; CD319; CRACC; CS1; CRACC]
• Short Name: [SLAMF7/CS1/CD319]
• Other Product Names: [SLAM family member 7 isoform b; SLAM family member 7; SLAM family member 7; SLAM family member 7; CD2 subset 1; CD2-like receptor-activating cytotoxic cells; CRACC; Membrane protein FOAP-12; Novel Ly9; Protein 19A; CD_antigen: CD319]
• NCBI GI Number: 543583691
• NCBI Accession Number: NP_001269517.1
• NCBI GB Accession Number: NP_001269517.1
• Uniprot Accession Number: Q9NQ25