SLAMF7/CS1/CD319

• Gene Name:

  [SLAMF7]

• NCBI Gene ID:

  57823

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  CS1, also known as novel Ly9, SLAMF7, 19A24 or CRACC, is a homophilic cell surface receptor. It is a member of the SLAM (signaling lymphocytic activation molecule) family of receptors expressed on natural killer (NK) cells, T cells and stimulated B cells. CS1 contains immunoreceptor tyrosine-based switch motifs in its cytoplasmic domain but, unlike other SLAM receptors, it does not recruit SAP (SLAM-associated protein). In humans, CS1 activates NK cells through an EAT-2-mediated pathway that is SAP-independent. CS1 recruits and associates with EAT-2, a protein closely related to SAP. EAT-2 induces phosphorylation of CS1 which then, upon ligand binding, activates downstream cytotoxicity effectors PLC and PI 3K. In mice, the EAT-2 association with CS1 has an inhibitory effect on the activation of NK cells.

• Other Gene Names:

  [SLAMF7; SLAMF7; 19A; CS1; CD319; CRACC; CS1; CRACC]

• Short Name:

  [SLAMF7/CS1/CD319]

• Other Product Names:

  [SLAM family member 7 isoform b; SLAM family member 7; SLAM family member 7; SLAM family member 7; CD2 subset 1; CD2-like receptor-activating cytotoxic cells; CRACC; Membrane protein FOAP-12; Novel Ly9; Protein 19A; CD_antigen: CD319]

• NCBI GI Number:

  543583691

• NCBI Accession Number:

  NP_001269517.1

• NCBI GB Accession Number:

  NP_001269517.1

• Uniprot Accession Number:

  Q9NQ25