Spectrin beta III (SPTBN2)

Spectrin beta III (SPTBN2)

• Gene Name: [SPTBN2]
• NCBI Gene ID: 6712
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Vertebrate spectrins have two alpha-subunits (alpha-I/alpha-II) four beta-subunits (beta-I-beta-IV) and a beta-H subunit creating diversity and specialization of function. Spectrin and spectrin are present in erythrocytes, whereas spectrin II (also designated fodrin) and spectrin I (also designated fodrin) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Spectrin III is highly homologous to both spectrin I and spectrin II. Spectrin III is highly expressed in brain, kidney, pancreas and liver, and at lower levels in lung and placenta. Spectrin beta 3 is primarily expressed in nervous tissues with highest expression levels in the cerebellum, where it is found in Purkinje cell soma and dendrites.
• Other Gene Names: [SPTBN2; SPTBN2; SCA5; SCAR14; GTRAP41; KIAA0302; SCA5]
• Short Name: [Spectrin beta III (SPTBN2)]
• Other Product Names: [spectrin beta chain, non-erythrocytic 2; Spectrin beta chain, non-erythrocytic 2; spectrin beta chain, non-erythrocytic 2; spectrin beta, non-erythrocytic 2; Beta-III spectrin; Spinocerebellar ataxia 5 protein]
• NCBI GI Number: 5902122
• NCBI Accession Number: NP_008877.1
• NCBI GB Accession Number: NP_008877.1
• Uniprot Accession Number: O15020