Anti-Spectrin beta III (SPTBN2)(SPTBN2/3142R)
CAT:
37-BNUB3142-500
Size:
500 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-Spectrin beta III (SPTBN2)(SPTBN2/3142R)
- Description: Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Vertebrate spectrins have two alpha-subunits (alpha-I/alpha-II) four beta-subunits (beta-I-beta-IV) and a beta-H subunit creating diversity and specialization of function. Spectrin III is highly expressed in brain, kidney, pancreas and liver, and at lower levels in lung and placenta. Spectrin beta 3 is primarily expressed in nervous tissues with highest expression levels in the cerebellum, where it is found in Purkinje cell soma and dendrites. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Synonyms: Beta III spectrin; SCA5; Spectrin beta chain brain 2; Spectrin beta non-erythrocytic 2; Spectrin non-erythroid beta chain 2; Spinocerebellar ataxia 5; SPTBN2
- CAS Number: 9007-83-4
- UNSPSC: 41116161
- UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
- Gene Name: SPTBN2
- Gene ID: 6712
- NCBI Gene ID: 26915
- UniProt: O15020
- Cellular Locus: Plasma membrane
- Host: Rabbit
- Species Reactivity: Human
- Immunogen: Recombinant fragment (around aa356-475) of human SPTBN2 protein (exact sequence is proprietary)
- Target Antigen: Spectrin Beta-III
- Clonality: Recombinant Monoclonal
- Isotype: IgG
- Clone: SPTBN2/3142R
- Conjugation: Purified, with BSA
- Source: Animal
- Applications: Flow, intracellular (verified) | IF (verified) | IHC, FFPE (verified) | WB (verified)
- Validated Applications: FC, IF, IHC, FFPE, WB
- Positive Control: PANC-1, HeLa, PC-3 cells. Brain, Pancreas or Liver.
- Concentration: 0.2 mg/mL
- Buffer: PBS, 0.05% BSA, 0.05% azide
- Molecular Weight: 246 kDa
- Shipping Conditions: Room temperature
- Storage Conditions: 4°C; Stable at room temperature or 37°C (98°F) for 7 days.
- Shelf Life: 2 years