CD11b/MAC-1 (Microglial Marker)

CD11b/MAC-1 (Microglial Marker)

• Gene Name: [CD11b/MAC-1]
• NCBI Gene ID: 3684
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin M2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. The protein CD11b has been implicated in the various adhesion-related interactions of cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. It is part of a heterodimer that consists of CD11b and CD18. It also modulates the uptake of complement-coated particles within the cell. It is commonly used as a microglial marker in tissues derived from the nervous system.
• Other Gene Names: [ITGAM; ITGAM; CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6; CD11B; CR3A]
• Short Name: [CD11b/MAC-1]
• Other Product Names: [integrin alpha-M isoform 1; Integrin alpha-M; integrin alpha-M; integrin subunit alpha M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor]
• NCBI GI Number: 224831239
• NCBI Accession Number: NP_001139280.1
• NCBI GB Accession Number: NP_001139280.1
• Uniprot Accession Number: P11215