Interleukin 10 (IL10) (Immunoregulation Marker)

Interleukin 10 (IL10) (Immunoregulation Marker)

• Gene Name: [IL10]
• NCBI Gene ID: 3586
• Reactivity: Human
• Storage Conditions: Antibody without azide, store at -20 to -80°C.
  Antibody is stable for 12 months.
  Non-hazardous.
  No MSDS required.
• Specificity: Interleukin 10 (IL10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immuno-regulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immuno-regulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
• Other Gene Names: [IL10; IL10; CSIF; TGIF; GVHDS; IL-10; IL10A; IL-10; CSIF]
• Short Name: [Interleukin 10 (IL10)]
• Other Product Names: [interleukin-10; Interleukin-10; interleukin-10; interleukin 10; Cytokine synthesis inhibitory factor; CSIF]
• NCBI GI Number: 10835141
• NCBI Accession Number: NP_000563.1
• NCBI GB Accession Number: NM_000572.3
• Uniprot Accession Number: P22301