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BTX-7312

CAT: 0804-HY-161235-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-161235-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BTX-7312 is a cereblon-based SOS1 bifunctional degrader and a molecular glue. BTX-7312 reduces downstream signaling markers pERK and pS6 and shows antiproliferative activity in various KRAS-mutated cells[1].
UNSPSC
12352005
Target
Molecular Glues; Ras; SOS1
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/btx-7312.html
Purity
98.35
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(F)C1=CC([C@@H](C)NC2=NC(Cl)=NC3=C2CN(C(C4(OC)CCN(C(CCCCN5CCC(C6=CC(CN(C7CCC(NC7=O)=O)C8=O)=C8C=C6F)CC5)=O)CC4)=O)C3)=CC(N)=C1
Molecular Formula
C45H52ClF4N9O6
Molecular Weight
926.40
References & Citations
[1]Begovich K, et al. Cereblon-Based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple KRAS Mutations and Inhibits Tumor Growth. Mol Cancer Ther. 2024 Jan 15.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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