CKD-731

CAT: 0804-HY-103653Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-103653Size:1 Each
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Description
CKD-731 is a Fumagillin (HY-B0751) analogue. CKD-731 inhibits the proliferation of calf pulmonary artery endothelial cells (CPAE), lymphoma EL-4 cells and murine leukemia P388D1 cells. CKD-731 exerts the effect of inhibiting MetAP-2 activity and blocking angiogenesis. CKD-731 can be used for the research of anti-angiogenesis-related cancer[1].
CAS Number
[251111-15-6]
UNSPSC
12352005
Target
MetAP
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Cardiovascular Disease
Smiles
O=C(O[C@H](CC1)[C@@H](OC)[C@H]([C@@]2(C)O[C@@H]2C/C=C(C)\C)[C@]31CO3)/C=C/C4=CC(OC)=C(OC)C(OC)=C4
Molecular Formula
C28H38O8
Molecular Weight
502.60
References & Citations
[1]Han CK, et al. Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2. Bioorg Med Chem Lett. 2000 Jan 3;10 (1) :39-43.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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