CKD-731

• Description :

  CKD-731 is a Fumagillin (HY-B0751) analogue. CKD-731 inhibits the proliferation of calf pulmonary artery endothelial cells (CPAE), lymphoma EL-4 cells and murine leukemia P388D1 cells. CKD-731 exerts the effect of inhibiting MetAP-2 activity and blocking angiogenesis. CKD-731 can be used for the research of anti-angiogenesis-related cancer[1].

• UNSPSC :

  12352005

• Target :

  MetAP

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cancer; Cardiovascular Disease

• Smiles :

  O=C(O[C@H](CC1)[C@@H](OC)[C@H]([C@@]2(C)O[C@@H]2C/C=C(C)\C)[C@]31CO3)/C=C/C4=CC(OC)=C(OC)C(OC)=C4

• Molecular Formula :

  C28H38O8

• Molecular Weight :

  502.60

• References & Citations :

  [1]Han CK, et al. Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2. Bioorg Med Chem Lett. 2000 Jan 3;10 (1) :39-43.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [251111-15-6]